New York, March 21 (IANS) A team of US researchers has identified 17 new genetic variants that may increase the risk of Alzheimer’s disease, an advance to boost future treatment and prevention strategies for the neurodegenerative disease.
The team from Boston University School of Public Health (BUSPH) and the University of Texas Health employed whole genome sequencing to find the 17 significant variants associated with Alzheimer’s in five genomic regions. The results may help researchers to find rare and important genes and variants.
“By using whole genome sequencing in a diverse sample, we were able to not only identify novel genetic variants associated with Alzheimer’s disease risk in known genetic regions but also characterise whether the known and novel associations are shared across populations,” says study co-lead and corresponding author Chloe Sarnowski, Assistant Professor in the Department of Epidemiology at UTHealth.
For the study, the researchers conducted whole genome sequencing on data including more than 95 million variants among 4,567 participants with or without the disease.
Of the 17 significant variants, the team found that the KAT8 variant was most notable. KAT8 was linked with the neurodegenerative disease in “both the single and rare variant analyses”.
Associations were also found with several rare TREM2 variants, the team said.
–IANS
rvt/svn
Disclaimer
The information contained in this website is for general information purposes only. The information is provided by BhaskarLive.in and while we endeavour to keep the information up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, or related graphics contained on the website for any purpose. Any reliance you place on such information is therefore strictly at your own risk.
In no event will we be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this website.
Through this website you are able to link to other websites which are not under the control of BhaskarLive.in We have no control over the nature, content and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them.
Every effort is made to keep the website up and running smoothly. However, BhaskarLive.in takes no responsibility for, and will not be liable for, the website being temporarily unavailable due to technical issues beyond our control.
For any legal details or query please visit original source link given with news or click on Go to Source.
Our translation service aims to offer the most accurate translation possible and we rarely experience any issues with news post. However, as the translation is carried out by third part tool there is a possibility for error to cause the occasional inaccuracy. We therefore require you to accept this disclaimer before confirming any translation news with us.
If you are not willing to accept this disclaimer then we recommend reading news post in its original language.
