New Delhi, Nov 25 (IANS) The US scientists have decoded why obesity increases the risk of type 2 diabetes by targeting the fat cells.
The study, published in Cell Reports, may advance new treatments for type 2 diabetes and other chronic diseases that work by helping fat stem cells differentiate and make new, smaller fat cells.
In a first, the team from the University of California-Los Angeles (UCLA) showed that obesity can make it difficult for the body to produce key cellular building blocks called ribosomal factors.
Without sufficient ribosomal factors, fat stem cells cannot produce functioning fat cells. Their energy gets trapped and they become enlarged and play a crucial role in diabetes development.
While fat tissue has been blamed for long, it’s “actually essential for maintaining normal glucose metabolism,” said Dr. Claudio Villanueva, Associate Professor of integrative biology and physiology at the University of California-Los Angeles.
Villanueva explained that people with obesity carry “too much fat tissue which is also not functioning optimally”.
Fat tissue stores energy from food. However, when not functioning properly, the excess energy gets rerouted to be stored elsewhere in the body like in the liver — leading to fatty liver disease; or in the heart — leading to atherosclerosis or stroke.
The study included obese and diabetic mice. The fat cells of these mice were four to five times larger than those found in lean mice. The team administered them with rosiglitazone.
The results showed that their ribosomal factors increased to normal levels, which triggered their fat stem cells to differentiate to produce new, smaller fat cells. Further, this enabled the mice’s fat tissue to function properly in storing energy. These also generate key hormones that regulate metabolism.
However, the scientists found that although the mice remained obese after taking the drug, their “type 2 diabetes essentially disappeared,”.
–IANS
rvt/
Disclaimer
The information contained in this website is for general information purposes only. The information is provided by BhaskarLive.in and while we endeavour to keep the information up to date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the website or the information, products, services, or related graphics contained on the website for any purpose. Any reliance you place on such information is therefore strictly at your own risk.
In no event will we be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this website.
Through this website you are able to link to other websites which are not under the control of BhaskarLive.in We have no control over the nature, content and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them.
Every effort is made to keep the website up and running smoothly. However, BhaskarLive.in takes no responsibility for, and will not be liable for, the website being temporarily unavailable due to technical issues beyond our control.
For any legal details or query please visit original source link given with news or click on Go to Source.
Our translation service aims to offer the most accurate translation possible and we rarely experience any issues with news post. However, as the translation is carried out by third part tool there is a possibility for error to cause the occasional inaccuracy. We therefore require you to accept this disclaimer before confirming any translation news with us.
If you are not willing to accept this disclaimer then we recommend reading news post in its original language.
